Determination of median effective dose (ED50 ) of scorpion antivenom against scorpion envenomation using a newly developed formula

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Reduction of Purification Time of Polyspecific Equine F(ab´)2 Antivenom against Scorpion Envenomation

Background and Aims: In this study we improved the purification of immunoglobulins from equine antiserum raised against the venom of 6 types of scorption species. Caprylic acid (octanoic acid), a fatty acid, was found to have no effect on the activity of the enzymes pepsin, which is used in antivenom purification to digest Fc fragment of immunoglobulins to obtain F(ab´)2. Materials and Methods...

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Unusual presentations of scorpion envenomation.

Scorpions are nocturnal arthropods that inject their venom through the victims' skin by stingers. By the envenomation, clinical manifestations in a wide spectrum may occur, including pain at one side and death because of severe cardiopulmonary or neurological abnormalities. Sometimes the victim cannot describe the insect or does not remember even being stung after the event. We present two case...

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Effectiveness of anti scorpion venom for red scorpion envenomation.

OBJECTIVE To study the efficacy of anti-scorpion venom plus prazocin. METHODS Comparison of clinical features, outcome and duration of stay between children receiving anti-scorpion venom plus prazocin or prazocin alone for management of red scorpion envenomation. RESULTS Requirement for dopamine and requirement and duration of dobutamine therapy were significantly less in patients received ...

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Scorpion Envenomation in Naama, Algeria

In Algeria scorpion envenomation represents a real public health problem with a population at risk of scorpion stings estimated at 68% of the national population. A total of 903, 461 scorpion sting cases and 1996 deaths were recorded by health services between 1991 and 2012. The physical-geographic and climate conditions make the province of Naama a conducive environment for scorpion species an...

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Cardiac arrest following scorpion envenomation.

Scorpion stings are a common occurrence in Saudi Arabia. The majority of cases present with local pain at the site of envenomation, and follow a benign clinical course. Severe systemic toxicity and mortality are uncommon. Reported deaths have been attributed to a primary effect of the venom on the cardiovascular system. Toxicity of envenomation varies between species and within the same species...

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ژورنال

عنوان ژورنال: Animal Models and Experimental Medicine

سال: 2018

ISSN: 2576-2095

DOI: 10.1002/ame2.12031